Publications

  • Levengood, J. D., Potoyan, D., Penumutchu. S., Kumar, A., Wang, Y., Hansen, A.L., Kutluay S.B., Roche, J., Tolbert, B. S. Thermodynamic coupling of the tandem RRM domain of hnRNP A1 underlie its pleiotropic RNA-binding functions. bioarxiv. 2023 Aug 17:2023.08.17.553700
  • Whitworth, I.T., Knoener, R.A., Puray-Chavez, M., Halfman, P., Romero, S., Baddouh, M., Kawaoka, Y., Kutluay, S. B., Smith, L.M., Sherer, N.M. Defining distinct RNA-protein interactomes of SARS-CoV-2 genomic and subgenomic RNAs. J. Proteome Res. 2023 (accepted)
  • Zeng, Q., Antia A., Puray-Chavez, M., Kutluay, S. B., Ding, S. Calpain-2 mediates SARS-CoV-2 entry and represents a therapeutic target. bioarxiv. 2022 Nov 29:2022.11.29.518418
  • Shema Mugisha, C., Dinh, T., Kumar, A., Tenneti, K., Eschbach, J.E., Davis, K., Gifford, R., Kvaratskhelia, M., Kutluay, S. B. Emergence of compensatory mutations reveal the importance of electrostatic interactions between HIV-1 integrase and genomic RNA. mBio. 2022 e0043122. Link to article
  • Puray-Chavez, M., Lee, N., Tenneti, K., Wang, Y., Vuong, H. R., Liu, Y., Horani, A., Huang, T., Gunsten, S. P., Case, J. B., Yang, W., Diamond, M. S., Brody, S. L., Dougherty, J., Kutluay, S. B. The translational landscape of SARS-CoV-2-infected cells reveals suppression of innate immune genes. mBio. 2022 e0081522. Link to article
  • Puray-Chavez, M.*, LaPak, K. M.*, Schrank, T. P., Elliott, J. L., Bhatt, D. P., Agajanian, M. J., Jasuja, R., Lawson, D. Q., Davis, K., Rothlauf, P. W., Liu, Z., Jo, H., Lee, N., Tenneti, K., Eschbach, J.E., Shema Mugisha, C., Cousins, E. M., Cloer, E.W., Vuong, H.R., VanBlargan, L.A., Bailey, A.L., Gilchuk, P., Crowe, J.E., Diamond, M. S., Hayes, D. N., Whelan, S. P. J., Horani, A., Brody, S. L., Goldfarb, D., Major, M. B.#, Kutluay, S.B.# Systematic analysis of SARS-CoV-2 infection of an ACE2 negative human airway cell.  Cell Reports. 2021 Jul 13; 36(2):109364 (# co-corresponding, * co-first) Link to article
  • Carter, C., Kutluay, S.B. Interview with a retrovirologist: Sebla B. Kutluay in conversation with Carol Carter. Retrovirology. 2021 Jul 1; 18(1):18 Link to article
  • Zafferani, M., Haddad, C., Luo, L., Davila-Calderon, J., Yuan-Chiu, L., Shema Mugisha, C., Monaghan, A.G., Kennedy, A.A., Yesselman, J.D., Gifford, R.R.,  Tai, A.W., Kutluay, S.B.,  Li, M.,  Brewer, G.,Tolbert, B.S., Hargrove, A.E. 2021. Amilorides inhibit SARS-CoV-2 replication by in vitro targeting of RNA structures. Science Advances 7(48):eabl6096. Link to article
  • Wang, Q., Gao, H., Clark, K. M., Shema Mugisha, C., Davis, K., Tang, P., Harlan, G. H., DeSelm, C. J., Presti, R. M., Kutluay, S. B., Shan, L. 2021. CARD8 is an inflammasome sensor for HIV-1 protease activity. Science 371(6535):eabe1707 Link to article
  • Shema Mugisha, C., Vuong, H.R., Puray-Chavez, M. Kutluay, S.B. 2020. A simplified Q-RT-PCR assay for monitoring SARS-CoV-2 growth in cell culture. mSphere 5 (5) e00658-20; DOI: 10.1128/mSphere.00658-20 Link to article
  • Eschbach, J. E., Elliott, J. L., Li, W., Zadrozny, K. K., Davis, K., Mohammed, S., Lawson, D. Q., Pornillos, O., Engelman, A.N., Kutluay, S. B. 2020. Capsid lattice destabilization leads to premature loss of the viral genome and integrase enzyme during HIV-1 infection. Journal of Virology. 95 (2) DOI: 10.1128/JVI.00984-20 Link to article
  • Elliott, J.L. and Kutluay, S.B. 2020 Going beyond integration: The emerging role of HIV-1 integrase in virion morphogenesis. Viruses, 12(9), 1005. (Invited review). Link to article
  • Elliott, J. L., Eschbach, J. E., Koneru, P., Li, W., Puray-Chavez, M., Townsend, D., Lawson, D. Q., Engelman, A.N., Kvaratskhelia, M., Kutluay, S. B. 2020 Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis. eLife. 9:e54311 DOI: 10.7554/eLife.54311. ELife Link to article
  • Kutluay, S.B.*, Emery, A., Penumutchu, S., Townsend, D., Tenneti, K., Madison, M. K., Stukenbroeker, A. M., Powell, C., Jannain, D., Tolbert, B. S., Swanstrom, R. I., Bieniasz, P. D.* 2019. Genome wide analysis of hnRNP binding to HIV-1 RNA reveals a key role for hnRNP H1 in alternative viral mRNA splicing. J. Vir. 93 (21) e01048-19. (*co-corresponding) Link to article
  • Bieniasz, P. D. and Kutluay, S. B. 2018. CLIP-related methodologies and their application to retrovirology. Retrovirology 15(1):35.
  • Williams, G. D., Townsend, D., Wylie, K. M., Kim, P. J., Amarasinghe, G. K., Kutluay, S. B., Boon, A. C. M. 2018. Nucleotide resolution mapping of influenza A virus nucleoprotein-RNA interactions reveals RNA features required for virus replication. Nat. Commun. 9(1): 465. Link to article
  • Madison, M. K., Lawson, D. Q., Elliott, J., Ozanturk, A. N., Koneru, P. C., Townsend, D., Errando, M., Kvaratskhelia, M., Kutluay, S.B. 2017. Allosteric integrase inhibitors lead to premature degradation of the viral RNA genome and integrase in target cells. Journal of Virology 91(17). pii: e00821-17. Link to article
  • Kessl, J. J.*, Kutluay, S. B.*, Townsend, D., Slaughter, A., Larue, R. C., Shkriabai, N., Bakouche, N., Fuchs, J. R., Bieniasz, P. D., Kvaratskhelia, M. 2016. HIV-1 integrase binds the viral RNA genome and is essential during virion morphogenesis. Cell 166(5): 1257-1268 (*equal contribution). Link to article
  • York, A.*, Kutluay, S.B.*, Errando, M., Bieniasz, P.D. 2016. The RNA binding specificity of human APOBEC3 proteins resembles that of HIV-1 nucleocapsid. PLoS Pathogens 12(8):e1005833 (*equal contribution). Link to article
  • Kutluay, S.B. and Bieniasz, P.D. 2016. Analysis of HIV-1 Gag-RNA interactions by in cells and virions by CLIP-seq. In V. R. Prasad & G. V. Kalpana (Eds.) Methods Mol Biol. 1354:119-31 (co-corresponding authors). Link to article
  • Kutluay, S.B., Zang, T., Blanco-Melo, D., Powell, C., Jannain, D., Errando, M., Bieniasz, P.D. 2014. Global changes in the RNA binding specificity of HIV-1 Gag regulate virion genesis. Cell 159(5): 1096-109. Link to article
  • Kane, M., Yadav, S., Bitzegeio, J., Kutluay, S.B., Zang, T., Wilson, S., Schoggins, J., Rice, C., Yamashita, M., Hatziioannou, T., Bieniasz, P.D. 2013. Mx2 is an interferon-induced inhibitor of HIV-1 infection. Nature 502(7472): 563-6. Link to article
  • Soll, S.J., Wilson, S.J., Kutluay, S.B., Hatziioannou, T., Bieniasz, P.D. 2013. Assisted evolution enables HIV-1 to overcome a high TRIM5α-imposed genetic barrier to rhesus macaque tropism. PLoS Pathogens 9(9): e1003667. Link to article
  • Kutluay, S.B., Perez-Caballero, D., Bieniasz, P.D. 2013. Fates of retroviral core components during unrestricted and TRIM5-restricted Infection. PLoS Pathogens 9(3): e1003214. Link to article
  • Wilson, S.J., Schoggins, J.W., Zang, T., Kutluay, S.B., Jouvenet, N., Alim, M.A., Bitzegeio, J., Rice, C.M., Bieniasz, P.D. 2012. Inhibition of HIV-1 particle assembly by 2′,3′-cyclic-nucleotide 3′-phosphodiesterase. Cell Host Microbe 12(4): 585-97. Link to article
  • Kutluay, S.B., and Bieniasz, P.D. 2010. Analysis of the initiating events in HIV-1 particle assembly and genome packaging. PLoS Pathogens 6(11):e1001200. Link to article
  • Kutluay, S.B., and Triezenberg, S.J. 2009. Regulation of chromatin during herpes simplex virus type-1 infections. Biochimica et Biophysica Acta 1790(6):456-66. Link to article
  • Kutluay, S.B., and Triezenberg, S.J. 2009.Regulation of histone deposition on the herpes simplex virus type-1 genome during lytic infection. Journal of Virology 83(11):5835-45. Link to article
  • Kutluay, S.B., DeVos, S., Klomp, J.E., Triezenberg, S.J. 2009. Transcriptional coactivators are not required for herpes simplex virus type-1 immediate early gene expression during lytic infection. Journal of Virology 83(8): 3436-49. Link to article
  • Kutluay, S.B., Doroghazi, J., Roemer, M.E., Triezenberg, S.J. 2008. Curcumin inhibits herpes simplex virus immediate-early gene expression by a mechanism independent of p300/CBP histone acetyltransferase activity. Virology 373 (2): 239-47. Link to article

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